Where do genes come from? Traditionally, most models for new gene evolution invoke modifications of ancestral genes.
The human microbiome (microbial communities and their gene content) is composed of trillions of cells in multiple ecological niches. Although the lung was initially believed to be sterile in the normal host, recent data indicate that microbial communities are detectable in individuals without lung disease.
Bacterial pathogens have evolved a plethora of different adaptations that confer high-level resistance to certain antibiotics. However, it remains unclear whether the observed adaptations are randomly drawn from a much larger set of possibilities or represent the best of only a few options for obtaining resistance.
Poor electronic medical record (EMR) usability is detrimental to both clinicians and patients. A better EMR would provide concise, context sensitive patient data, but doing so entails the difficult task of knowing which data are relevant.
Mobile technologies such as smartphones and wearable sensors offer unprecedented opportunities to sense and intervene on patient health behaviors in real-time, in real-world contexts, and at enormous scale. This talk will highlight recent and ongoing patient-centered research using mobile sensing and machine learning to predict clinical cancer outcomes such as readmissions and treatment toxicities.
Epidemics can and should be forecast, to improve decision making by governments, institutions and individuals. The goal of the Delphi group at Carnegie Mellon University is to make epidemiological forecasting as universally accepted and useful as weather forecasting is today.
The overarching goal of Dr. Jonassaint’s program of research is to improve behavioral and physical health and reduce health disparities by using mobile multimedia technology to deliver evidence-based interventions to underserved populations.
Genome scale molecular datasets are often highly structured, with many correlated observations. This general phenomenon can be related to the underlying data generating process.