An Overview of a Translational Research Program
Translational research occurs along a continuum with two phases. The first is from bench to clinical research and the second from clinical research to stakeholders, such as patients, clinicians, and policymakers. I focus on the latter phase and describe studies using methods from different disciplines, including informatics, information science, and psychology. All entail analysis of language expressed in text. For example, we conducted a study involving feature engineering and a proposed decision-support system for systematic reviewers. In another, we developed a terminology for comparative effectiveness study designs, evaluated coverage in the controlled vocabularies for MEDLINE and Embase, and considered differences in sublanguages. I also briefly describe a maturing program in dentistry about dissemination, implementation, and adherence to clinical practice guidelines. As a precursor to a series of information retrieval studies, we are developing a gold standard for prognostic biomarker studies of oral squamous cell carcinoma with content views, including multi document, sentence-based summaries. I conclude by describing a scoping review of telemedicine in nursing homes and offer preliminary data as to why such reviews are essential for prioritizing topics and identifying research gaps.