Publications for Richard Boyce, PhD

2020

Grizzle AJ, Hines LE, Malone DC, Kravchenko O, Hochheiser H, Boyce RD. Testing the face validity and inter-rater agreement of a simple approach to drug-drug interaction evidence assessment. J Biomed Inform. 2020 Jan;101:103355. doi: 10.1016/j.jbi.2019.103355. Epub 2019 Dec 12. PMID: 31838211; DOI: 10.1016/j.jbi.2019.103355.

Villa Zapata, L., Hansten, P.D., Horn, J.R. et al. Evidence of Clinically Meaningful Drug–Drug Interaction With Concomitant Use of Colchicine and Clarithromycin. Drug Saf (2020). https://doi.org/10.1007/s40264-020-00930-7

Jhon Camacho, Manuela Zanoletti-Mannello, Zach Landis-Lewis, Sandra L. Kane-Gill, Richard D. Boyce.  A Conceptual Framework to Study the Implementation of Clinical Decision Support Systems (BEAR): Literature Review and Concept Mapping.  Journal of Medical Internet Research, 2020 Aug 6;22(8):e18388. doi: 10.2196/18388.  PMID: 32759098

Birer-Williams C, Gufford BT, Cho E, Alilio M, VanAlstine S, Morley RE, McCune JS, Paine MF, Boyce RD.  A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: from Chemical Characterization to Clinical Studies. Drug Metabolism and Disposition.  Drug Metabolism and Disposition 2020 Jun 29;DMD-AR-2020-000054.

doi: 10.1124/dmd.120.000054. PMID: 32601103

Kane-Gill SL, Wong A, Culley CM, Perera S, Reynolds MD, Handler SM, Kellum JA, Aspinall M, Pellett M, Long K, Nace D, Boyce RD. Transforming the medication regimen review process of high-risk drugs using a patient-centered telemedicine-based approach to prevent adverse drug events in the nursing home. Journal of American Geriatric Society 2020 Nov 24. doi:10/1111/jgs.16946. PMID: 33233016 PMCID: In Progress.

2019

Grizzle AJ, Horn J, Collins C, Schneider J, Malone DC, Stottlemyer B, Boyce RD. Identifying Common Methods Used by Drug Interaction Experts for Finding Evidence About Potential Drug-Drug Interactions: Web-Based Survey. J Med Internet Res. 2019 Jan 4;21(1):e11182. doi:10.2196/11182. PMID: 30609981.

Nguyen BP, Reese T, Decker S, Malone D, Boyce RD, Beyan O. Implementation of Clinical Decision Support Services to Detect Potential Drug-Drug Interaction Using Clinical Quality Language.

Stud Health Technol Inform. 2019 Aug 21;264:724-728. doi: 10.3233/SHTI190318. PubMed PMID: 31438019.

2018

Judkins J, Tay-Sontheimer J, Boyce RD, Brochhausen M. Extending the DIDEO ontology to include entities from the natural product drug interaction domain of discourse. J Biomed Semantics. 2018 May 9;9(1):15. doi: 10.1186/s13326-018-0183-z. PMID: 29743102. PMCID: PMC59444177.

Camacho J, Medina Ch. AM, Landis-Lewis Z, Douglas G, Boyce R. Comparing a Mobile Decision Support System Versus the Use of Printed Materials for the Implementation of an Evidence-Based Recommendation: Protocol for Qualitative Evaluation. JMIR Res Protoc 2018;7(4):e104. doi: 10.2196/resprot.9827. PMID: 29653921. PMCID: PMC5924374.

Boyce RD, Ragueneau-Majlessi I, Yu J, Tay-Sontheimer J, Kinsella C, Chou E, Brochhausen M, Judkins J, Guffort BT, Pinkleton BE, Cooney R, Paine MF, McCune JS. Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers. AMIA Annu Symp Proc. 2018 Dec 5;2018:279-287. eCollection 2018. PMID: 30815066. PMCID: PMC6371317.

2017

Boyce RD, Jao J, Miller T, Kane-Gill SL. Automated Screening of Emergency Department Notes for Drug-Associated Bleeding Adverse Events Occurring in Older Adults. Appl Clin Inform. 2017 Oct; 8(4):1022-1030. doi: 10.4338/ACI-2017-02-RA-0036. Epub 2017 Dec 14. PMID: 29241242.

Voss EA, Boyce RD, Ryan PB, van der Lei J, Rijnbeek PR, Schuemie MJ. Accuracy of an Automated Knowledge Base for Identifying Drug Adverse Reactions. J Biomed Inform. 2017 Feb;66:72-81. doi: 10.1016/j.jbi.2016.12.005. PubMed PMID: 27993747. PubMed Central PMCID: PMC5316295. 

Boyce RD, Voss E, Huser V, Evans L, Reich C, Duke JD, Tatonetti NP, Lorberbaum T., Dumontier M, Hauben M, Wallberg M, Peng L, Dempster S, He O, Sena A, Koutkias V, Natsiavas P, Ryan P. (Knowledge Base Workgroup of the Observational Health Data Sciences and Informatics [OHDSI] collaborative). Large-scale Adverse Effects Related to Treatment Evidence Standardization (LAERTES): an Open Scalable System for Linking Pharmacovigilance Evidence Sources with Clinical Data. J Biomed Semantics. 2017 Mar 7;8(1):11. doi: 10.1186/s13326-017-0115-3. PubMed PMID: 28270198. PubMed Central PMCID: PMC5341176.

Romagnoli KM, Nelson SD, Hines L, Empey P, Boyce RD, Hochheiser, H. Information Needs for Making Clinical Recommendations about Potential Drug-Drug Interactions: a Synthesis of Literature Review and Interviews. BMC Med Inform Decis Mak. 2017 Feb 22;17(1):21. doi: 10.1186/s12911-017-0419-3. Review. PubMed PMID: 28228132. PubMed Central PMCID: PMC5322613.

Utecht J, Brochhausen M, Judkins J, Schneider J, Boyce RD. Formalizing Evidence Type Definitions for Drug-Drug Interaction Studies to Improve Evidence Base Curation. Stud Health Technol Inform. 2017;245:960-964. PMID: 29295242. PMCID: PMC5765984.

Freimuth RR, Formea CM, Hoffman JM, Matey E, Peterson JF, Boyce RD. Implementing Genomic Clinical Decision Support for Drug-Based Precision Medicine. CPT Pharmacometrics Syst Pharmacol. 2017 Mar;6(3):153-155. Doi: 10.1002/psp4.12173. Review. PubMed PMID: 28109071. PubMed Central PMCID: PMC5351408.

Kane-Gill SL, Niznik JD, Kellum JA, Culley CM, Boyce RD, Marcum ZA, He H, Perera S, Handler, SM. Use of Telemedicine to Enhance Pharmacist Services in the Nursing Facility. Consult Pharm. 2017 Feb 1;32(2):93-98. doi: 10.4140/TCP.n.2017.93. Pub Med PMID: 28569660. PubMed Central PMCID: PMC5454780.

Romagnoli KM, Boyce RD, Empey PE, Ning Y, Adams S, Hochheiser H. Design and evaluation of a pharmacogenomics information resource for pharmacists. J Am Med Inform Assoc. 2017 Jul 1;24(4):822-831. doi: 10.1093/jamia/ocx007. PMID: 28339805.

2016

Romagnoli KM, Boyce RD, Empey PE, Adams S, Hochheiser H. Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements. Int J Med Inform. 2016 Feb;86:54-61. doi: 10.1016/j.ijmedinf.2015.11.015. Epub 2015 Nov 30. PMID: 26725696. PMCID: PMC4720137.

Hochheiser H, Ning Y, Hernandez A, Horn, JR, Jacobson R, Boyce RD. Using Nonexperts for Annotating Pharmacokinetic Drug-Drug Interaction Mentions in Product Labeling: A Feasibility Study. JMIR Res Protoc. 2016 Apr 11;5(2):e40. doi: 10.2196/resprot.5028. PMID: 27066806 PMCID: PMC4844909.

Samwald M, Xu H, Blagec K, Empey PE, Malone DC, Ahmed SM, Boyce RD, et al. (2016) Incidence of Exposure of Patients in the United States to Multiple Drugs for Which Pharmacogenomic Guidelines Are Available. PLoS ONE 11(10): e0164972. PMID: 27764192  DOI: 10.1371/journal.pone.0164972

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing. Home Data from Multiple Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252. PubMed PMID: 27891528. DOI: http://dx.doi.org/10.13063/2327-9214.1252

Huser V, DeFalco F, Schuemie M, Ryan P, Shang N, Velez M, Park RW, Boyce RD, Duke J, Khare R, Utidjian L, Bailey C. (2016) "Multisite Evaluation of a Data Quality Tool for Patient-Level Clinical Datasets," eGEMs (Generating Evidence & Methods to improve patient outcomes): Vol. 4: Iss. 1, Article 24. DOI: http://dx.doi.org/10.13063/2327-9214.1239

2015

Scheife RT, Hines LE, Boyce RD, Chung SP, Momper JD, Sommer CD, Abernethy DR, Horn JR, Sklar SJ, Wong SK, Jones G, Brown ML, Grizzle AJ, Comes S, Wilkins TL, Borst C, Wittie MA, Malone DC. Consensus Recommendations for Systematic Evaluation of Drug-Drug Interaction Evidence for Clinical Decision Support. Drug Saf. 2015 Jan 3.  http://link.springer.com/article/10.1007%2Fs40264-014-0262-8  [Epub ahead of print] PubMed PMID: 25556085. [PMCID – in process]

Samwald M, Miñarro Giménez JA, Boyce RD, Freimuth RR, Adlassnig K-P, Dumontier M. Pharmacogenomic knowledge representation, reasoning and genome-based clinical decision support based on OWL 2 DL ontologies. BMC MedRical Informatics and Decision Making. 2015;15:12. doi:10.1186/s12911-015-0130-1.  PubMed4340468

Pfundner A, Schönberg T, Horn J, Boyce RD, Samwald M. Utilizing the Wikidata system to improve the quality of medical content in Wikipedia in diverse languages: a pilot study. Journal of Medical Internet Research. 2015; 17(5). http://www.jmir.org/2015/5/e110/ .PMCID: PMC4468594

Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), 206-217.  DOI:10.1016/j.jbi.2015.04.006. PMID 25917055

2014

Boyce RD, Ryan PB, Noren N. et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest.  Drug Safety. 2014. DOI: 10.1007/s40264-014-0189-0

Boyce RD, Perera S, Nace DA, Culley CM, Handler SM. A survey of nursing home physicians to determine laboratory monitoring adverse drug event alert preferences. Appl Clin Inf 2014; 5: 895-906. DOI: 10.4338/ACI-2014-06-RA-0053. [PMCID – in process]

Schneider J, Ciccarese P, Clark T, Boyce RD. Using the Micropublications ontology and the Open Annotation Data Model to represent evidence within a drug-drug interaction knowledge base. The 4th Workshop on Linked Science 2014— Making Sense Out of Data (LISC2014). Collocated with the 13th International Semantic Web Conference (ISWC2014). October 19th and 20th, Riva del Garda, Trentino, Italy.

Brochhausen M, Schneider J, Malone D, Empey PE, Hogan WR, Boyce RD. Towards a foundational representation of potential drug-drug interaction knowledge. The 1st International Drug-Drug Interaction Knowledge Representation Workshop (DIKR 2014). Collocated with the 2014 International Conference on Biomedical Ontology (ICBO 2014). October 6th, Houston, Texas. United States.

Giménez JAM, Blagec K, Boyce RD, Adlassnig KP, Samwald M. An Ontology-Based, Mobile-Optimized System for Pharmacogenomic Decision Support at the Point-of-Care. PLOS ONE. 2014 May. 9(5). DOI: 10.1371/journal.pone.0093769. PubMed PMID: PMID: 24787444. PMCID: PMC4008421

Ayvaz S, Zhu Q, Hochheiser H, Brochhausen M, Horn J, Dumontier M, … Boyce RD. (2014). Drug-Drug Interaction Data Source Survey and Linking. AMIA Summits on Translational Science Proceedings, 2014, 16. PMID: 25717393 PMCID: PMC4333686

2013

Rasteger-Mojarad M, Boyce RD, Prasad R. UWM-TRIADS: Classifying Drug-Drug Interactions with Two-Stage SVM and Post-Processing. Proceedings of the 2013 International Workshop on Semantic Evaluation (SemEval), Task 9 - Extraction of Drug-drug Interactions from BioMedical Texts. Atlanta Georgia, June 2013.

Rasteger-Mojarad, M., Boyce RD., Prasad, R. UWM-TRIADS: Classifying Drug-Drug Interactions with Two-Stage SVM and Post-Processing. Proceedings of the 2013 International Workshop on Semantic Evaluation (SemEval), Task 9 - Extraction of Drug-drug Interactions from BioMedical Texts. Atlanta Georgia, June 2013.

Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Biomed Semantics. 2013 Jan 26;4(1):5. [Epub ahead of print] DOI 10.1186/2041-1480-4-5 PMID:23351881. [PMCID – in process]

Hassanzadeh O, Zhu Q, Freimuth RR, Boyce R. Extending the “Web of Drug Identity” with Knowledge Extracted from United States Product Labels. Proceedings of the 2013 AMIA Summit on Translational Bioinformatics. San Francisco, March 2013. 

Handler SM, Boyce RD, Ligons FM, Perera S, Nace DA, Hochheiser H. Use and Perceived Benefits of Mobile Devices by Physicians in Preventing Adverse Drug Events in the Nursing Home. Journal of The American Medical Directors Association. 2013 Oct 2. PMID: 24094901.

Boyce RD, Freimuth RR, Romagnoli KM, Pummer T, Hochheiser H, Empey PE. Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support. 2013; 28-32. PMCID: PMC3814496. PMID: 24303292.

Handler SM, Boyce RD, Ligons F, Perera S, Nace DA, Hochheiser H. (2013). Use and Perceived Benefits of Mobile Devices by Physicians in Preventing Adverse Drug Events in the Nursing Home. Journal of the American Medical Directors Association, 14(12), 906–910. http://doi.org/10.1016/j.jamda.2013.08.014 PMID: 24094901 PMCID: PMC4351260

2012

Boyce RD, Handler SM, Karp JF, Hanlon JT. Age-related Changes in Antidepressant Pharmacokinetics and Potential Drug-Drug Interactions: A Comparison of Evidence-Based Literature and Package Insert Information. Am J Geriatr Pharmcother. DOI:10.1016/j.amjopharm.2012.01.001. PMID: 22285509.

Marshall MS, Boyce RD, Deus H, Zhao J, Willighagen E, Samwald M, Pichler E, Hajagos J, Prud’hommeaux E, Stephens S. Emerging practices for mapping life sciences data to RDF - a case series. Journal of Web Semantics. Special Issue: Reasoning with Context in the Semantic Web. (In Press).

Boyce RD, Collins C, Clayton M, Kloke J, Horn J. Inhibitory Metabolic Drug Interactions with Newer Psychotropic Drugs: Inclusion in Package Inserts and Influences of Concurrence in Drug Interaction Screening Software. Annals of Pharmacotherapy. Volume 46. Epub 2012 Oct 2. DOI 10.1345/aph.1R150. PMID: 23032655

Rodríguez-González A, Pathak J, Wilkinson MD, Shah NH, Stevens R, Boyce RD, García-Crespo Á. “Proceedings of the Joint Workshop on Semantic Technologies Applied to Biomedical Informatics and Individualized Medicine (SATBI+SWIM 2012),” Held at the 11th International Semantic Web Conference (ISWC 2012), November 12th, Boston, USA. http://ceur-ws.org/Vol-930/

Marshall MS, Boyce RD (Eds). Health Care and Life Science (HCLS) Linked Data Guide. World Wide Web Consortium (W3C). November 2012. http://www.w3.org/2001/sw/hcls/notes/hcls-rdf-guide/. 

2011

Staheli JP, Boyce R, Kovarik D, Rose TM. CODEHOP PCR and CODEHOP PCR primer design. Methods Mol Biol. 2011;687:57-73. PMID: 20967601.

Boyce RD, Hanlon JT, Karp JF, Kloke J, Saleh A, Handler SM. A Review of the Effectiveness of Antidepressant Medications for Depressed Nursing Home Residents, Journal of the American Medical Directors Association, 2011 Oct 20. DOI:10.1016/j.jamda.2011.08.009. PMID:22019084. 

Peron EP, Marcum ZA, Boyce R, Hanlon JT, Handler SM. Year in Review: Medication Mishaps in the Elderly.  Am J Geriatr Pharmacother. 2011 Feb; 9(1):1-10. PMID 21459304.

2010

Marcum ZA, Handler SM, Boyce R, Gellad W, Hanlon JT.  Medication Misadventures in the Elderly: A Year in Review.  Am J Geriatr Pharmacother. 2010 Feb;8(1):77-83. PMID: 20226395  PMCID: PMC2904235

2009

Boyce R, Rose T, Chilana P. “iCODEHOP:  a new interactive program for designing COnsensus-DEgenerate Hybrid Oligonucleotide Primers (CODEHOPs) from multiply-aligned protein sequences,” Nucleic Acids Research, 2009 Jul 1;37(Web Server issue):W222-8, PMID: 19443442  PMCID: PMC2703993.

Boyce R, Collins C, Horn J, Kalet I, Computing with evidence part I: A drug-mechanism evidence taxonomy oriented toward confidence assignment, Journal of Biomedical Informatics, 2009, 2009 Dec;42(6):979-89, PMID:   PMCID: PMC2783801.

Boyce R, Collins C, Horn J, Kalet I. Computing with evidence part II: an evidential approach to predicting metabolic drug-drug interactions, Journal of Biomedical Informatics, 2009 Dec;42(6):990-1003. PMID: 19539050 PMCID: PMC2783683.

2007

Boyce R, Collins C, Horn J, Kalet I. "Modeling Drug Mechanism Knowledge Using Evidence and Truth Maintenance," IEEE Transactions on Information Technology in Biomedicine, Volume 11(4) 2007, Page(s):386 - 397. PMID: 17674621.

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