Uma Chandran, PhD, MSIS

Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation

Kevin Louis, Camila Macedo, Elodie Bailly, Louis Lau, Bala Ramaswami, Marilyn Marrari, Douglas Landsittel, Alexander Chang, Uma Chandran, Paul Fadakar, Masaki Yamada, Geetha Chalasani, Parmjeet Randhawa, Adriana Zeevi, Harinder Singh, Carmen Lefaucheur, Diana Metes. Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation.  Journal of the American Society of Nephrology, 2020 Jul 28;ASN.2020030320.  doi: 10.1681/ASN.2020030320

 

ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells

Wang Z, Pascal LE, Chandran UR, Chaparala S, Lv S, Ding H, Qi L, Wang Z.  ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells.  Cancer Management and Research 2020 Jun 10;12:4411-4427. doi: 10.2147/CMAR.S248854. PMID: 32606936 PMCID:  PMC7294050

Multiple antigen-engineered DC vaccines with or without IFNα to promote antitumor immunity in melanoma

Butterfield LH, Vujanovic L, Santos PM, Maurer DM, Gambotto A, Lohr J, Li C, Waldman J, Chandran U, Lin Y, Lin H, Tawbi HA, Tarhini AA, Kirkwood JM. Multiple antigen-engineered DC vaccines with or without IFNα to promote antitumor immunity in melanoma. J Immunother Cancer. 2019 Apr 24;7(1):113. doi: 10.1186/s40425-019-0552-x. PubMed PMID: 31014399.

Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma

Faden DL, Concha-Benavente F, Chakka AB, McMichael EL, Chandran U, Ferris RL. Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma. Head Neck. 2019 Mar 4. doi: 10.1002/hed.25726. [Epub ahead of print]. PMID: 30828910.

IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury

Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt B, Thomson AW, Fan MH, BIlliar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury. JCI Insight. 2019 Feb 19. pii: 123919. doi: 10.1172/jci.insight.123919. Epub ahead of print. PMID: 20779711.

A Comparison of the Sexually Dimorphic Dexamethasone Transcriptome in Mouse Cerebral Cortical and Hypothalamic Embryonic Neural Stem Cells

Frahm KA, Waldman JK, Luthra S, Rudine AC, Monaghan-Nichols AP, Chandran UR, DeFranco DB. A Comparison of the Sexually Dimorphic Dexamethasone Transcriptome in Mouse Cerebral Cortical and Hypothalamic Embryonic Neural Stem Cells. Mol Cell Endocrinol. 2018 Aug 15;471:42-50.. doi: 10.1016/j.mce.2017.05.026. PubMed PMID: 28554804. PMCID: PMC5702594.

Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms

Carson RA, Rudine AC, Tally SJ, Franks AL, Frahm KA, Waldman JK, Silswal N, Burale S, Phan JV, Chandran UR, Monaghan AP, DeFranco DB. Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms. PLoS One. 2018 May 8;13(5):e0196387. doi: 10.1371/journal.pone.0196387. eCollection 2018. PMID: 29738356.

HDAC5-LSD1 Axis Regulates Antineoplastic Effect of Natural HDAC Inhibitor Sulforaphane in Human Breast Cancer Cell

Cao C, Wu H, Vasilatos SN, Chandran U, Qin Y, Wan Y, Oesterrich S, Davidson NE, Huang Y. HDAC5-LSD1 Axis Regulates Antineoplastic Effect of Natural HDAC Inhibitor Sulforaphane in Human Breast Cancer Cells. Int J Cancer. 2018 Sep 15;143(6):1388-1401. doi: 10.1005/ijc.31419. Epub 2018 Apr 20. PMID 29633255. PMCID: PMC6105499 [Available on 2019-09-15]

EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer.

Pascal LE, Wang Y, Zhong M, Wang D, Chakka AB, Yang Z, Li F, Song Q, Rigatti LH, Chaparala S, Chandran U, Parwani AV, Wang Z. EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer. Neoplasia. 2018 Apr;20(4):351-363. doi: 10.1016/j.neo.2018.01.011. Epub 2018 Mar 6. PMID: 29518696. PMCID: PMC5909677.

Expression of reactive species related genes is associated with patient survival in luminal B breast cancer

Luthra S, Chandran U, Diergaarde B, Becich M, Lee AV, Neumann CA. Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. Free Radic Biol Med. 2018 Mar 12. pii: S0891-5849(18)30114-X. doi: 10.1016/j.freeradbiomed.2018.03.011. [Epub ahead of print]. PMID: 2954507.

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