David Boone, PhD

Room 414
5607 Baum Boulevard
dnb14@pitt.edu
Phone: 
412-648-7231
Admin Support: 
Lucy Cafeo
Links: 
Overview »
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Research Interests: 

Development and implementation of STEM outreach programs

-Insulin-like Growth Factor 1 (IGF1) signaling in breast cancer

-Regulation and function of long noncoding RNAs (lncRNAs)

-Transcription and transcriptomics

-Breast cancer biology

Assistant Professor, Director of CoSBBI
Executive Director of the UPCI Academy
Department of Biomedical Informatics
University of Pittsburgh School of Medicine
Department of Biomedical Informatics
Publications: 

Nagle AM, Levine KM, Tasdemir N, Scott JA, Burlbaugh K, Kehm JW, Katz TA, Boone DN, Jacobsen BM, Atkinson JM, Oesterreich S, Lee AV. Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R/InsR inhibitors. Clin Cancer Res. 2018 Jun 25. pii: clincanres.0279.2018. doi: 10.1158/1078-0432.CCR-18-0279. [Epub ahead of print]. PMID: 29941485.

Chen J, Nagle AM, Wang YF, Boone DN, Lee AV. Controlled dimerization of insulin-like grown factor-1 and insulin receptors reveal shared and distinct activities of holo and hybrid receptors. J Biol Chem. 2018 Mar 9;293(10):3700-3709. doi: 10.1074/jbc.M117.789503. Epub 2018 Jan 12. PMID: 23990302.

Warburton AJ, Boone DN. Insights of Global Analyses of Long Noncoding RNAs in Breast Cancer. Curr Pathobiol Rep. 2017 Mar;5(1):23-34. doi: 10.1007/s40139-017-0122-1. Epub 2017 Jan 23. PubMed PMID: 28616363. PubMed Central PMCID: PMC5467540.

King AJ, Fisher AM, Becich MJ, Boone DN. Computer Science, Biology and Biomedical Informatics academy: Outcomes from 5 years of Immersing High-school Students into Informatics Research. J Pathol Inform. 2017 Feb 28;8:2. doi: 10.4103/2153-3539.201110. eCollection 2017. PMID: 28400991 PMC ID: 5359992.

Nayak S, Harrington E, Boone DN, Hartmaier R, Pathiraja, T, Cooper K, Fine J, Sanfilippo J, Davidson N, Lee AV, Dabbs D, and Oesterreich S. A Role for Histone H2B Variants in Endocrine Resistant Breast Cancer. Hormones and Cancer. 2015  PUBMED 26113056

Farabaugh SM, Boone DN, and Lee AV. Role of IGF1R in breast cancer subtypes, stemness, and lineage differentiation.  Frontiers in Endocrinology. 2015. PUBMED 25964777

Zhang Q, Spears E, Boone DN, Li Z, Gregory M, and Hann S.  Domain specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activitys.  PNAS. 2012; 110(3):978-83. PUBMED 23277542

Boone DN and Lee AV. Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression Profiling. Critical Reviews in Oncogenesis.  2012;17(2):161-73. PUBMED 22471706

Boone DN and Hann SR. The Myc-ARF-Egr1 Pathway: Unleashing Myc’s Apoptotic Power.  Cell Cycle.  2011 Jul1;10(13):2043-4.  PMC3234342

Boone DN, Qi Y, Li Z, and Hann S. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. PNAS. 2011 Jan 11;108(2):632-7.  PUBMED 21187408

Zhaoliang Li, Boone D, and Hann S.  Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.  PNAS.  2008 Dec 2;105(48):18794-9. PUBMED 19033198

van Rheede T, Bastiaans T, Boone D, Hedges SB, de Jong W, and Madsen O.  2006. The platypus is in its place: nuclear genes and indels confirm the sister group relation of monotremes and therians. Mol. Biol. Evol. 23:587-597. PMID:19033198

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