Environmental adaptation and genetic mutations in developing antibiotic resistance

Seminar Date: 
Seminar Time: 
11am - 12pm
Seminar Location: 
5607 Baum Boulevard, Room 407A
Y.P. Peter Di, PhD
Presenter's Institution: 
University of Pittsburgh

Despite many prevention measurements and successful development of vaccines against SARS-CoV2, the COVID-19 pandemic continuously affects our life likely for many years to come. The emerging delta variant from the evolving virus showed the critical role of the mutations in infections. Viruses and bacteria become successful pathogens by finding ways to adapt to the host environment. Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous, Gram-negative opportunistic pathogen that could cause animal and human diseases in certain conditions. It is one of the most important virulent pathogens that contribute to cystic fibrosis (CF) morbidity and mortality. P. aeruginosa can chronically colonize in CF lungs, where it persists for decades and frequently exists as biofilms. We hypothesize that CF lung pathogenic microenvironment favors the colonization and growth of P. aeruginosa, and they thrive in the CF lung through environmental adaption. This presentation will provide an overview of the threats and mechanisms of antimicrobial resistance, the adaption/evolution of pathogenic bacteria in selected host environments, and the exciting development of novel antimicrobials overcoming multidrug-resistant bacterial infection.