Clinical Trials and Tribulations in a Global Pandemic
Data scientists have been at the forefront of helping to resolve the COVID pandemic. Their roles to address numerous critical questions have been integral to finding solutions to the pandemic. Our team has responded on numerous fronts but has primarily focused efforts on the design and analysis of clinical trials to establish optimal treatments for COVID-19 in the outpatient setting. We have proposed a shared infrastructure for the design and analysis of outpatient COVID-19 trials at our institution that includes a pragmatic platform protocol. The COVID-19 Outpatient Pragmatic Platform Study (COPPS) was designed to be flexible and efficient. I will discuss the journey to establish this trial including the challenges, lessons learned, and some solutions.