Remodeling the tumor microenvironment to improve the efficacy of immunotherapy in patients with advanced melanoma

Seminar Date: 
Seminar Time: 
11am - 12pm
Seminar Location: 
5607 Baum Boulevard, Room 407A
Yana Najjar, MD
Presenter's Institution: 
Division of Hematology-Oncology, UPMC Hillman Cancer Center

The treatment paradigm of patients with advanced melanoma has changed drastically with the advent of anti-PD1 based immunotherapy. However, in spite of unprecedented response rates, the fact remains that many patients do not respond to treatment. We will discuss the role of tumor cell metabolism in advanced melanoma, its impact on the tumor microenvironment, and how the tumor microenvironment may be remodled so that more patients can benefit from immunotherapy.