Congruence Analysis of Model Organisms (CAMO)
Model organisms have been widely used in biomedical research to replace human studies and to reduce cost and experimental time in initial biomedical exploration. Recent contradictory reports on whether mouse models mimic human in transcriptomic response (PNAS, 2013 3507-3512; PNAS, 2015 1167-1172) have created debates on usefulness of animal models. Instead of a dichotomous “yes”/“no” answer, we have developed a statistical evaluation framework with functional characterization for comparison of differential transcriptomic systems across model organisms or across species. I will present its application to three transcriptomic examples.