Capturing the complex interplay between drugs and the intestinal microbiome

Birer C, Wright ES. Capturing the complex interplay between drugs and the intestinal microbiome. Clin Pharmacol Ther. 2019 May 18. doi: 10.1002/cpt.1505. [Epub ahead of print] PubMed PMID: 31102465

Predicting drug interactions, disposition, and side effects is central to the practice of clinical pharmacology. Until recently, the human microbiome has been an underappreciated player in the dynamics of drug metabolism. It is now clear that humans are 'superorganisms' with about tenfold more microbial cells than human cells and harboring an immense diversity of microbial enzymes. Owing to the advent of new technologies, we are beginning to understand the human microbiome's impact on clinical pharmacology

Publication Year: 
2019
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Birer C, Wright ES
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