SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Nargund AM, Osmanbeyoglu HU, Cheng EH, Hsieh JJ. SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer. Mol Cell Oncol. 2017 Jun 19;4(4):e1342747. doi: 10.1080/23723556.2017.1342747. eCollection 2017. PubMed PMID: 28868352. PMCID: PMC5540208.

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

Publication Year: 
2017
Publication Credits: 
Nargund AM, Osmanbeyoglu HU, Cheng EH, Hsieh JJ
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