Multi-omics data analysis in asthma in Puerto Rican Children
Asthma is a major cause of healthcare costs in children, particularly in the high-risk subgroup, Puerto Ricans. We aim to identify susceptibility genes for asthma in Puerto Ricans. We conducted GWAS and EWAS of asthma. We also conducted mQTL, eQTL and eQTM analyses to test for association between the top SNPs and DNA methylation and gene expression in nasal epithelium. We identified multiple SNPs, CpG sites and expressed genes associated with asthma.