Discovering novel peptide natural products by integrating computational mass spectrometry and genome mining
Genomics studies revealed numerous antibiotics-encoding genes across a wide range of bacterial and fungal species, including various species in the human microbiome. However, little is known about the hundreds of antibiotics produced by microorganisms in the human, soil and other host-oriented/environmental microbiomes. Deep exploration of this meta-antibiome critically depends on a transition from the current one-off process of antibiotics analysis to a high-throughput antibiotics sequencing. I will discuss recent advances in computational antibiotics discovery that span bioinformatics techniques ranging from genome/metagenome sequencing to genome mining to peptidogenomics.
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