Erik S. Wright, PhD, MS

426 Bridgeside Point II
450 Technology Dr
Phone: 
412-383-4458
Website: 
Admin Support: 
Research Interests: 

Erik's research integrates experimental and computational approaches to tackle the problem of antibiotic resistance. Although antibiotics have been used by microorganisms for eons, it remains unclear how these organisms have mitigated the rise of antibiotic resistance in their competitors. Erik studies the strategies that naturally antibiotic-producing bacteria have evolved to discourage the build-up of resistance, how we might employ similar tactics in the clinic, and how some pathogens have adapted to overcome antibiotics while paying a minimal price for resistance. The goal of this research is to develop new strategies for treating infectious disease, ultimately turning the tide against increasing antibiotic resistance.

Education and Training:

PhD Microbiology @ UW-Madison
MS Civil & Environmental Engineering @ UW-Madison
BS Electrical & Computer Engineering @ Cornell University
 

Recent Publications:

View at Google Scholar

  Assistant Professor, Department of Biomedical Informatics

Publications: 

Murali A, Bhargava A, Wright ES. IDTAXA: a novel approach for accurate taxonomic classification of microbiome sequences. Microbiome. 2018 Sep;6:140. PMID:  30092815

Wright ES, Baum DA (2018). Exclusivity offers a sound yet practical species criterion for bacteria despite abundant gene flow. BMC Genomics. 2018 Oct;19(1):724. PMID: 30285620

Wright, ES, & Vetsigian KH (2018). Stochastic exits from dormancy give rise to heavy-tailed distributions of descendants in bacterial populations. bioRxiv. http://doi.org/10.1101/246629

Wright ES. Getting my feet wet. Science. 2017 Apr 7;356(6333):106. doi: 10.1126/science.356.6333.106. PMID: 28386014.

Wright ES, Vetsigian KH. DesignSignatures: a tool for designing primers that yields amplicons with distinct signatures. Bioinformatics. 2016 May 15;32(10):1565-7. doi: 10.1093/bioinformatics/btw047. Epub 2016 Jan 23. PMID: 26803162.

Wright ES, Vetsigian KH. Inhibitory interactions promote frequent bistability among competing bacteria. Nat Commun. 2016 Apr 21;7:11274. doi: 10.1038/ncomms11274. PMID: 27097658. PMCID: PMC4844671.

Wright ES, Vetsigian KH. Quality filtering of Illumina index reads mitigates sample cross-talk. BMC Genomics. 2016 Nov 4;17(1):876. doi: 10.1186/s12864-016-3217-x. PMID: 27814679. PMCID: PMC5097354.

Wright ES. DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment. BMC Bioinformatics. 2015 Oct 6;16:322. doi: 10.1186/s12859-015-0749-z. PMID: 26445311. PMCID: PMC4595117.

Wright ES, Yilmaz LS, Corcoran AM, Ökten HE, Noguera DR. Automated design of probes for rRNA-targeted fluorescence in situ hybridization reveals the advantages of using dual probes for accurate identification. Appl Environ Microbiol. 2014 Aug;80(16):5124-33. doi: 10.1128/AEM.01685-14. Epub 2014 Jun 13. PMID: 24928876. PMCID: PMC4135741.

Wright ES, Yilmaz LS, Ram S, Gasser JM, Harrington GW, Noguera DR. Exploiting extension bias in polymerase chain reaction to improve primer specificity in ensembles of nearly identical DNA templates. Environ Microbiol. 2014 May;16(5):1354-65. doi: 10.1111/1462-2920.12259. Epub 2013 Sep 24. PMID: 24750536.

Noguera DR, Wright ES, Camejo P, Yilmaz LS. Mathematical tools to optimize the design of oligonucleotide probes and primers. Appl Microbiol Biotechnol. 2014 Dec;98(23):9595-608. doi: 10.1007/s00253-014-6165-x. Epub 2014 Oct 31. Review. PMID: 25359473.

Wright ES, Yilmaz LS, Noguera DR. DECIPHER, a search-based approach to chimera identification for 16S rRNA sequences. Appl Environ Microbiol. 2012 Feb;78(3):717-25. doi: 10.1128/AEM.06516-11. Epub 2011 Nov 18. PMID: 22101057. PMCID: PMC3264099.

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