DBMI Special Seminar - Jonathan C. Chen, PhD will be presenting on October 10 at 11AM

Special Seminar

You are invited to a Special Seminar on Monday, October 10th.

Dr. Jonathan H. Chen, MD, PhD, Stanford University, Department of Medicine, will be presenting a seminar on Monday, October 10th, at 11:00 AM titled “Wisdom of the Crowd or Tyranny of the Mob?  Data-Mining Electronic Health Records for Clinical Decision Support”


Medical decision making is fraught with both uncertainty and undesirable variability. The vast majority of our clinical decisions lack adequate evidence to determine their efficacy and inconsistent implementation compromises quality and efficiency.

The current standards in clinical decision support reinforce best-practices but are limited in scalability by manual production. “Grand challenges” thus include mining clinical data sources to automatically generate decision support content.

Statistical approaches allow us to learn patterns that reflect real-world standards of care vs. outliers. This can range from my evaluation of the national distribution of opioid prescriptions to my current NIH Big Data 2 Knowledge K01 Career Development Award directed to empower individual clinicians with the collective experience of the many.

I will review my efforts developing a collaborative filtering machine-learning approach to clinical order entry, analogous to Netflix or Amazon.com’s “Customer’s who bought A also bought B” algorithm. This automatically generated decision support content can reproduce, and even optimize, manual constructs like order sets while remaining largely concordant with guidelines and avoiding inappropriate recommendations. This has even more important implications for prevalent cases where well-defined guidelines do not exist. The same methodology is predictive of clinical outcomes comparable to state-of-the-art risk prediction models. Embedded randomization of such decision support interventions could then allow us to explicitly build knowledge for the future, even as we enhance care today, in a closed-loop learning health system.


Department of Biomedical Informatics
5607 Baum Blvd., Fourth Floor, Conference Room 407 A/B
Pittsburgh, PA 15206



Linda Mignogna


Post Date: 
Friday, September 9, 2016