Douglas Landsittel, PhD
Dr. Landsittel has worked for the last 20 years in the areas of occupational injury and exposures, biomarkers and prognostic models, and more recently causal inference. After receiving his PhD in Biostatistics from the University of Pittsburgh (1997), he assumed a number of leadership positions across three different divisions/labs of the National Institutes for Occupational Safety and Health (NIOSH). His subsequent positions at the University of Pittsburgh (in the departments of Biostatistics and Medicine) included serving as the Associate Director of Biostatistics for the University of Pittsburgh Cancer Institute and the Associate Director of the Center for Research on Healthcare Data Center.
He is the PI of the Data Coordinating and Imaging Analysis Center for the NIDDK Consortium for Radiological Imaging Studies of Polycystic Kidney Disease (PKD), or CRISP IV, which is an NIDDK-funded study of prognostic factors for chronic kidney disease and end-stage renal disease in PKD that has been ongoing for over 15 years. He is also completing a statistical methods contract funded by the Patient-Centered Outcomes Research Institute (PCORI) to develop a Decision Tool for Causal Inference and Observational Data Analysis Methods in Comparative Effectiveness Research (DECODE CER). In terms of collaborative research, he has published over 120 manuscripts and is the Director of Biostatistics for the basic science faculty in the Starzl Transplant Institute, and is a Core Faculty Member of the Comparative Effectiveness Research Center and the Center for Research on Healthcare. He also collaborates with faculty in Rheumatology, Surgery, and Nephrology.
Dr. Landsittel serves on a number of national committees and expert panels. He was an appointed member (2013-2017) of the NIH Kidney, Nutrition, Obesity and Diabetes Study Section, and serves on an ad hoc basis for review committees through PCORI, NIOSH, the Department of Defense, and several NIH agencies. He is also a member of the Editorial Board for the Journal of Clinical Oncology (since 2013), an NIDDK External Expert Committee, and an NIDDK Data Safety Monitoring Board for a large pragmatic trial. He previously served on national working groups for studying pesticide exposure and transplant allocation methods.
Lavu S, Vaughan LE, Senum SR, Kline TL, Chapman AB, Perrone RD, Mrug M, Braun WE, Steinman TI, Rahbari-Oskoui FE, Brosnahan GM, Bae KT, Landsittel D, Chebib FT, Yu ASL, Torres VE, the HALT PKD and CRISP Student Investigators, Harris PC. The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD. JMI Insight, 2020 Aug 6;5(15):138724. doi: 10.1172/jci.insight.138724. PMID: 32634120
Kevin Louis, Camila Macedo, Elodie Bailly, Louis Lau, Bala Ramaswami, Marilyn Marrari, Douglas Landsittel, Alexander Chang, Uma Chandran, Paul Fadakar, Masaki Yamada, Geetha Chalasani, Parmjeet Randhawa, Adriana Zeevi, Harinder Singh, Carmen Lefaucheur, Diana Metes. Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation. Journal of the American Society of Nephrology, 2020 Jul 28;ASN.2020030320. doi: 10.1681/ASN.2020030320
Wang LF, Li Y, Landsittel DP, Reis SE, Levesque MC, Jones DM, Gartland R, Avolio J, Shoushtari A, Qi Z, Dezfulian C, Moreland LW, Liang KP. Identifying Vulnerable Plaque in Rheumatoid Arthritis Using Novel Microbubble Contrast-Enhanced Carotid Ultrasonography and Serum Biomarkers. Journal of Diagnostic Medical Sonography 27 May 2020. https://doi.org/10.1177/8756479320922512
Hayek SS, Landsittel DP, Wei C, Zeier M, Yu ASL, Torres VE, Roth S, Pao CS, Reiser J. Soluble Urokinase Plasminogen Activator Receptor and Decline in Kidney Function in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2019 Jun 6. doi: 10.1681/ASN.2018121227. [Epub ahead of print] PubMed PMID: 31171572.
Bae KT, Shen C, Landsittel DP, Zhao W, Wu Z, Tao C, Chapman AB, Torres VE, Yu ASL, Mrug M, Bennett B, Flessner MF, Harris PC. Growth pattern of kidney cyst number and volume in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2019 Jun 7;14(6):823-833. doi: 10.2215/CJN.10360818. Epub 2019 May 14. PubMed PMID: 31088850.
Macedo C, Hadi K, Walters J, Elinoff B, Marrai M, Zeevi A, Ramaswami B, Chalasani G, Landsittel D, Shields A, Alloway R, Woodle ES, Lakkis F, Metes D. Impact of Induction Therapy on Circulating T Helper Cells and Subsequent Donor-Specific Antibody Formation After Kidney Transplant. Kidney Int Rep. 2019 Mar;4(3):455-469. doi: 10.1016/j.ekir.2018.11.020. PubMed PMID: 30899873. PMCID: PMC6409398.
Yu ASL, Shen C, Landsittel DP, Grantham JJ, Cook LT, Torres VE, Chapman AB, Bae KT, Mrug M, Harris PC, Rahbari-Oskoui FF, Flessner MF, Bennett WM. Long-term trajectory of kidney function in autosomal dominant polycystic kidney disease. Kidney Int. 2019 May;95(5):1253-1261. doi: 10.1016/j.kint.2018.12.023. Epub 2019 Mar 4. PubMed PMID: 30922668.
Mtonga, T., & Douglas, G. P. (2019). Standardizing Representation of Medication in LMICs: Case of Malawi and RxNORM. Journal of Health Informatics in Africa, 6(2), 51 - 56. https://doi.org/10.12856/JHIA-2019-v6-i2-230.
Schnetz MP, Hochheiser HS, Danks DJ, Landsittel DP, Vogt KM, Ibinson JW, Whitehurst SL, McDermott SP, Duque MG, Kaynar AM. The triple variable index combines information generated over time from common monitoring variables to identify patients expressing distinct patterns of intraoperative physiology. BMC Med Res Methodol. 2019 Jan 14;19(1):17. doi: 10.1186/s12874-019-0660-9. PMID: 30642260. PMCID: PMC6332613.
Radovic A, Li Y, Landsittel D, Stein BD, Miller E. A Social Media Website (Supporting Our Valued Adolescents) to Support Treatment Uptake for Adolescents With Depression and/or Anxiety and Their Parents: Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2019 Jan 23;8(1):e12117. doi: 10.2196/12117. PMID: 30672741. PMCID: PMC6264211.
Petrov AA, Traister RS, Crespo MM, Silveira FP, Xie M, Coffey K, Ensor CR, Landsittel D, Pilewski JM.A Prospective Observational Study of Hypogammaglobulinemia in the First Year After Lung Transplantation. Transplant Direct. 2018 Jul 12;4(8):e372. doi: 10.1097/TXD.0000000000000811. eCollection 2018 Aug. PMID: 30255132. PMCID: PMC6092181.
Puttarajappa CM, Hariharan S, Humar A, Paliwal Y, Gao X, Cruz RJ, Ganoza AJ, Landsittel D, Bhattarai M, Sogawa H. Outcomes of Adult Intestinal Transplant Recipients Requiring Dialysis and Renal Transplantation. Transplant Direct. 2018 Jul 20;4(8):e377. doi: 10.1097/TXD.0000000000000815. eCollection 2018 Aug. PubMed PMID: 30255137. PMCID: PMC6092176.
Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D, Shope T. Development and Validation of a Calculator for Estimating the Probability of Urinary Tract Infection in Young Febrile Children. JAMA Pediatr. 2018 Jun 1;172(6):550-556. doi: 10.1001/jamapediatrics.2018.0217. PMID: 29710324. PMCID: PMC6137527.
McKenzie KA, El Ters M, Torres VE, Harris PC, Chapman AB, Mrug M, Rabhari-Oskoui FF, Bae KT, Landsittel DP, Bennett WM, Yu ASL, Mahnken JD. Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: a retrospective analysis using the CRISP cohort. BMC Nephrol. 2018 Dec 27;19(1):378. doi: 10.1186/s12882-018-1182-0. PMID: 30591038. PMCID: PMC6307167.
Thurston RC, Chang Y, Barinas-Mitchell E, Jennings R, von Känel R, Landsittel DP, Matthews KA. Physiologically assessed hot flashes and endothelial function among midlife women. Menopause. 2017 Aug;24(8):886-893. doi: 10.1097/GME.0000000000000857. PMID: 28399007 PMCID: PMC5524590.
Hughes AM, Patterson PD, Weaver MD, Gregory ME, Sonesh SC, Landsittel D, Krackhardt D, Hostler D, Lazzara EH, Wang X, Vena J, Salas E, Yealy DM. Teammate familiarity, teamwork, and risk of workplace injury in EMS teams. J Emerg Nurs. 2017 Jul;43(4):339-346. doi: 10.1016/j.jen.2016.11.07. Epub 2017 Mar 30. PMID: 28366241.
Gao B, Long C, Lee W, Zhang Z, Gao X, Landisttel D, Ezzelarab M, Arares D, Liu Q, Cooper D, Hara H. Anti-Neu5Gc and anti-non-Neu5Gc antibodies in health humans. PLos One. 2017 Jul 17; 12(7):e0180768. doi: 10.1371/journal.pone.0180768. eCollection 2017. PMID: 28715486. PMCID: PMC 55134129.
Kline TL, Korfiatis P, Edwards ME, Bae KT, Yu A, Chapman AB, Mrug M, Grantham JJ, Landsittel D, Bennett WM, Flessner MF, King BF, Harris PC, Torres VE, Erickson BJ; CRISP Investigators. Image Texture Features Predict Renal Function Decline in Autosomal Dominant Polycystic Kidney Disease Patients. Kidney Int. 2017 Nov;92(5):1206-1216. doi: 10.1016/j.kint.2017.03.026. Epub 2017 May 20. PMID: 28532709. PMCID: PMC5651185.
Thurston RC, Chang Y, Mitchell EB, von Känel R, Jennings JR, Santoro N, Landsittel DP, Matthews KA. Child abuse and neglect and subclinical cardiovascular disease among midlife women. Psychosom Med. 2017 May;79(4): 441-449. doi: 10.1097/PSY.0000000000000400. PMID: 27763988 PMCID: PMC5477855.
Rosenberger EM, DeVito Dabbs AJ, DiMartini AF, Landsittel DP, Pilewski JM, Dew MA. Long-Term Follow-up of a Randomized Controlled Trial Evaluating a Mobile Health Intervention for Self-Management in Lung Transplant Recipients. Am J Transplant. 2017 May;17(5):1286–1293. doi: 10.1111/ajt.14062. Epub 2016 Oct 31. PMID: 27664940. PMCID: PMC5365382.
Sentell TL, Shen C, Landsittel D, Mays MH, Southerland J, King MH, Taira DA. Racial/ethnic differences in those accompanying Medicare patients to the doctor: Insights from the 2013 Medicare Current Beneficiary's Survey. J Immigr Minor Health. 2018 Aug 20:20(4):776-783. doi: 10.1007/s10903-017-0582-8. PMID: 28405871. PMCID: PMC5656534 [Available on 2019-08-01].
Shen C, Landsittel D, Irazabal MV, Yu ASL, Chapman AB, Mrug M, Grantham JJ, Bae KT, Bennett WM, Flessner MF, Torres VE. Performance of the CKD-EPI equation to estimate GFR in a longitudinal study of Autosomal Dominant Polycystic Kidney Disease. Am J Kidney Dis. 2017;69(3):482-484. doi: 10.1053/j.ajkd.2016.10.021. PMID:28027795. PMCID: PMC5497695.
Yu ASL, Shen C, Landsittel DP, Harris PC, Torres VE, Mrug M, Bae KT, Grantham JJ, Rahbari-Oskoui FF, Flessner MF, Bennett WM, Chapman AB; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP). Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2018 Mar; 93(3):691-699. doi: 10.1016/j.kint.2017.09.027. Epub 2017 Dec 28. PMID: 29290310. PMCID: PMC5826779.
Taira DA, Seto BK, Davis JW, Seto TB, Landsittel D, Sumida WK. Examining Factors Associated With Nonadherence And Identifying Providers Caring For Nonadherent Subgroups. J Pharm Health Serv Res. 2017 Dec;8(4):247-253. doi: 10.1111/jphs.12193. Epub 2017 Aug 7. PMID:29151900. PMCID: PMC5690547.
Taira DA, Shen C, King M, Landsittel D, Mays MH, Sentell T, Southerland J. Access to medications for medicare enrolees related to race/ethnicity: Results from the 2013 Medicare Current Beneficiary Survey. Res Social Adm Pharm. 2017 Nov; 13(6): 1208-1213. doi: 10.1016/j.sapharm.2016-10-021. Epub 2016 Nov 23. PMID:27914950. PMC ID: PMC5500432.
Landsittel DP, Kessler L, Schmid CH, Marantz P, Suarez-Almazor ME Training in patient-centered outcomes research for specific researcher communities. J Clin Transl Sci. 2017 Oct;1(5):278-284. doi: 10.1017/cts.2017.307. PMID: 29707248. PMCID: PMC5915813.
Cherukuri A, Salama AD, Carter CR, Landsittel D, Arumugakani G, Clark B, Rothstein DM and Baker RJ. Reduced Human Transitional B cell T1/T2 Ratio Is Associated with Subsequent Deterioration in Renal Allograft Function. Kidney International. 2017;91(1):183-195. PMID: 28029430 DOI: 10.1016/j.kint.2016.08.028
Liapis H, Gaut JP, Klein C, Bagnasco S, Kraus E, Farris AB, Honsova E, Perkowska-Ptasinska A, David D, Goldberg J, Smith M, Mengel M, Haas M, Seshan S, Pegas KL, Horwedel T, Paliwa Y, Gao X, Landsittel D, Randhawa P. Banff histopathological consensus criteria for pre-implantation kidney biopsies. Am J Transplant. 2017 Jan;17(1):140-150. doi: 10.1111/ajt.13929. Epub 2016 Jul 22. PMID: 27333454. PMCID: PMC6139430.
Dr. Landsittel is the Director of the Expanding National Capacity in PCOR through Training (ENACT) Program. ENACT is an AHRQ-funded program in partnership with the universities of Hawaii and Puerto Rico, Howard and Charles Drew universities, Meharry Medical College, and Morehouse School of Medicine. This program seeks to further develop infrastructure and expertise in patient-centered outcomes research (PCOR) at Minority-Serving Institutions. The ENACT Program includes two online courses on writing a PCOR concept proposal and a full application, and an experiential program, where Fellows train on-site in Pittsburgh for one month of the year. Dr. Landsittel also teaches the Publication and Presentation in Biomedical Informatics course and co-teaches a course in comparative effectiveness research (CER) in the Institute for Clinical Research Education (where he was previously the CER Track Director) and formerly taught in the Computational Mathematics Graduate Program at Duquesne University and the Graduate School of Public Health at Pittsburgh, were he still advises MS students and serves on the MS/MPH Program Committee. He is also a faculty member of the Biomedical Informatics Core Training Program, and is the Chair of the University Senate Educational Policies Committee.
Education and Training
BS, Applied Mathematics, University of Pittsburgh, 1992
PhD, Biostatistics, University of Pittsburgh, Graduate School of Public Health, 1997