Special Seminar presented by Lixing Yang, PhD - “The Landscape of Somatic Genome Rearrangements in Human Cancers”
You are invited to a Special Seminar on Tuesday, April 12th, given by Lixing Yang, PhD, Research Associate (Peter Park Lab), Harvard Medical School, Department of Biomedical Informatics.
Dr. Lixing Yang will be presenting a seminar on Tuesday, April 12th, at 11:00 AM titled “The Landscape of Somatic Genome Rearrangements in Human Cancers”
High-throughput sequencing technologies make identification of somatic genome rearrangements in cancer patients possible although many challenges remain. We developed a novel algorithm that can not only detect these events in high confidence, but also infer their underlying mechanisms. By analyzing over 800 whole-genome sequenced cancer patients across 19 tumor types, we found tremendous diversity in terms frequencies and types of somatic rearrangements among patients and across tumor types. The somatic events depend more on non-homologous based mechanisms compared to germline rearrangements. We identified many novel cancer-driving gene fusions and validated several by in vitro and in vivo assays. Furthermore, we found that ~4% of the patients have massively rearranged chromosomes, many of which are associated with up-regulation of oncogenes.