Faculty

Michael J. Becich, MD, PhD

Directory Listing Information
Becich, Michael J.
bioinformatics; biological markers; computational biology; computer communication networks; computer-assisted instruction; diagnostic imaging; gene expression regulation, neoplastic; imaging informatics; informatics; laboratories, hospital; medical informatics; next generation sequencing; pathology; translational research; personalized medicine
Dr. Becich is a Professor of Biomedical Informatics, Pathology, Clinical/Translational Sciences, Information Sciences/Telecommunications. He is the Chair of the Department of Biomedical Informatics and Associate Vice-Chancellor for the Health Sciences.
Room 521
5607 Baum Boulevard
Pittsburgh
PA
15206-3701
412-648-9244
412-624-5310
412-606-6453
http://www.dbmi.pitt.edu/person/michael-j-becich-md-phd
Chairman and Distinguished University Professor, Department of Biomedical Informatics
Professor of Pathology, Information Sciences, Telecommunications and Clinical/Translational Sciences
Associate Vice Chancellor for Informatics in the Health Sciences
Director, Center for Commercial Application (CCA) of Healthcare Data
Associate Director for Cancer Institute (UPCI)
Associate Director, Clinical and Translational Science Institute (CTSI)
University of Pittsburgh School of Medicine
Publications: 

Luthra S, Chandran U, Diergaarde B, Becich M, Lee AV, Neumann CA. Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. Free Radic Biol Med. 2018 Mar 12. pii: S0891-5849(18)30114-X. doi: 10.1016/j.freeradbiomed.2018.03.011. [Epub ahead of print]. PMID: 2954507.

Culbertson A, Goel S, Madden MB, Safaeinili N, Jackson KL, Carton T, Waitman R, Liu M, Krishnamurthy A, Hall L, Cappella N, Visweswaran S, Becich MJ, Applegate R, Bernstam E, Rothman R, Matheny M, Lipori G, Bian J, Hogan W, Bell D, Martin A, Grannis S, Klann J, Sutphen R, O’Hara AB, Kho A. The Building Blocks of Interoperability. A Multisite Analysis of Patient Demographic Attributes Available for Matching. Appl Clin Inform. 2017 Apr 5;8(2):322-336. doi: 10.4338/ACI-2016-11-RA-0196. PMID: 28378025.

King AJ, Fisher AM, Becich MJ, Boone DN. Computer Science, Biology and Biomedical Informatics academy: Outcomes from 5 years of Immersing High-school Students into Informatics Research. J Pathol Inform. 2017 Feb 28;8:2. doi: 10.4103/2153-3539.201110. eCollection 2017. PMID: 28400991 PMC ID: 5359992.

De Rienzo A, Cook RW, Wilkinson J, Gustafson CE, Amin W, Johnson CE, Oelschlager KM, Maetzold DJ, Stone JF, Feldman MD, Becich MJ, Yeap BY, Richards WG, Bueno R. Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues. J Mol Diagn. 2017 Jan;19(1):65-71. doi: 10.1016/j.jmoldx.2016.07.011. Epub 2016 Nov 15. Pub Med PMID: 27863259. PMCID: PMC5225306.

Uppal R, Mandava G, Romagnoli KM, King AJ, Draper AJ, Handen AL, Fisher AM, Becich MJ, Dutta-Moscato J. How can we improve Science, Technology, Engineering, and Math education to encourage careers in Biomedical and Pathology Informatics? J Pathol Inform. 2016 Jan 29;7:2. doi: 10.4103/2153-3539.175375. eCollection 2016. PMID: 26955500. PMCID: PMC4763503.

Jacobson RS, Becich MJ, Bollag RJ, Chavan G, Dhir R, Corrigan J, Feldman M, Ganguly A, Gaudioso C, Legowski E, Maihle N, Mitchell K, Murphy M, Sakthivel M, Tseytlin E, Weaver J. A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens. Cancer Res. 2015;75(24):5194-201.doi: 10.1158/0008-5472.CAN-15-1973. Review. PMID: 26670560 PMCID: PMC4683415.

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R, Center for Causal Discovery team. The Center for causal discovery of biomedical knowledge from Big Data. J Am Med Inform Assoc. 2015 Nov;22(6): 1132-6. doi: 10.1093/jamia/ocv059. Epub 2015 Jul 2.  PMID: 26138794. PMCID: PMC5009908.

Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HSBecich MJ, Zhang Y, Leader JK, Methé BA, Kaminski N, Sandhaus RA; GRADS Alpha-1 Study Group. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol.  Ann Am Thorac Soc. 2015 Oct; 12(10): 1551-60. doi: 10.1513/AnnalsATS.201503-143OC. PMID: 26153726. PMCID: PMC4627425.

Amin W, Tsui FC, Borromeo C, Chang CH, Espino JU, Ford D, Hwang W, Kapoor W, Lehmann H, Martich GD, Morton S, Paranjape A, Shirey W, Sorensen A, Becich MJ, Hess R. PaTH: towards a learning health system in the Mid-Atlantic region. J Am Med Inform Assoc. 2014;21(4):63-6 doi: 10.1136/amiajnl-2014-002759. Epub 2014 May 12. PMID: 24821745. PMCID: PMC4078296.

Amin W, Srinivasan M, Song SY, Parwani AV, Becich MJUse of automated image analysis in evaluation of mesothelioma Tissue Microarray (TMA) from National Mesothelioma Virtual Bank. Pathol Res Pract. 2014 Feb;210(2):79-82. doi: 10.1016/j.prp.2013.09.002. Epub 2013 Nov 14. PMID: 24359722.

Risinger JI, Allard J, Chandran U, Day R, Chandramouli GV, Miller C, Zahn C, Oliver J, Litzi T, Marcus C, Dubil E, Byrd K, Cassablanca Y, Becich M, Berchuck A, Darcy KM, Hamilton CA, Conrads TP, Maxwell GL. Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion. Front Oncol. 2013 Jun 17;3:139. doi: 10.3389/fonc.2013.00139. Print 2013. PMID: 23785665. PMCID: PMC3683664.

Park S, Parwani AV, Aller RD, Banach L, Becich MJ, Borkenfeld S, Carter AB, Friedman BA, Rojo MG, Georgiou A, Kayser G, Kayser K, Legg M, Naugler C, Sawai T, Weiner H, Winsten D, Pantanowitz L. The history of pathology informatics: A global perspective. J Pathol Inform. 2013 May 30;4:7. doi: 10.4103/2153-3539.112689. Print 2013. PMID: 23869286. PMCID: PMC3714902.

Amin W, Parwani A, Melamed J, Flores R, Pennathur A, Valdivieso F, Whelan N, Landreneau R, Luketich J, Feldman M, Pass H, Becich MJNational Mesothelioma Virtual Bank: A Platform for Collaborative Research and Mesothelioma Biobanking Resource to Support Translational Research. Lung Cancer International, Volume 2013, Article ID 765748.

Gullapalli RR, Desai KV, Santana-Santos L, Kant JA, Becich MJNext generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics. J Pathol Inform. 2012;3:40. doi: 10.4103/2153-3539.103013. Epub 2012 Oct 31. PMID:  23248761

Bartholow TL, Chandran UR, Becich MJ, Parwani AV. Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma. Diagn Pathol. 2011 Jan 21;6:12. PMID: 21255442. PMCID: PMC3033791. doi: 10.1186/1746-1596-6-12

Amin W, Singh H, Pople AK, Winters S, Dhir R, Parwani AV, Becich MJ. A decade of experience in the development and implementation of tissue banking informatics tools for intra and inter-institutional translational research. Journal of Pathology Informatics. 2010 Aug 10; 1.12. PMID: 20922029. PMCID: PMC2941965. doi: 10.4103/2153-3539.68314

Amin W, Parwani A, Schmandt L, Mohanty S, Farhat G, Pople A, Winters S, Whelan N, Schneider A, Milnes J, Valdivieso F, Feldman M, Pass H, Dhir R, Melamed J, Becich M. National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research. BMC cancer. 2008 Aug; 8(1): 236. PMID: 18700971. PMCID: PMC2533341

Yin M, Bastacky S, Chandran U, Becich MJ, Dhir R. Prevalence of incidental prostate cancer in the general population: a study of healthy organ donors. The Journal of Urology. 2008 Mar;179(3):892-5; discussion 895. PMID: 18207193 DOI: 10.1016/j.juro.2007.10.057

Mohanty S, Mistry A, Amin W, Parwani A, Pople A, Schmandt L, Winters S, Milliken E, Kim P, Whelan N, Farhat G, Melamed J, Taioli E, Dhir R, Pass H, Becich M. The development and deployment of Common Data Elements for tissue banks for translational research in cancer - an emerging standard based approach for the Mesothelioma Virtual Tissue Bank. BMC cancer 2008 Apr; 8(8): 91. PMID: 18397527. PMCID: PMC2329649

Chandran UR, Ma C, Dhir R, Bisceglia M, Lyons-Weiler J, Liang W, Michalopoulos GK, Becich MJ, Monzon FA. Gene expression profiles of metastatic prostate cancer reveals disregulation of specific molecular pathways. BMC Cancer. 2007;7(0):64. PMID: 17430594 PMCID: PMC1865555

Chandran UR, Dhir R, Ma C, Michalopoulos G, Becich M, Gilbertson J. (2005). Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors. BMC Cancer, 5, 45. http://doi.org/10.1186/1471-2407-5-45 PMID: 15892885 PMCID: PMC1173092

Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, Shah RB, Chandran U, Monzon FA, Becich MJ, Wei JT, Pienta KJ, Ghosh D, Rubin MA, Chinnaiyan AM. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer cell. 2005 Nov;8(5):393-406. PMID: 16286247

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