Complex Traits: Advanced Analytic Approaches to Identify Etiologic Genes
Abstract: Our group and others have demonstrated that common craniofacial and dental genetic traits and diseases like cleft lip with/out cleft palate (CL/P) possess a complex etiology, with heterogeneity in prevalence influenced by a variety of factors including geographic origin. These discoveries, in turn, have been facilitated by, and continue to fuel the development and use of sophisticated statistical approaches in our continuing effort to untangle the genetics of such complex traits. The posterior probability of linkage (PPL) is a class of likelihood-based, model-free statistics developed specifically to meet the challenge presented by complex traits. The PPL is a measure of the strength of evidence in favor of, or against, linkage and it accommodates inter- and intra-population heterogeneity using Bayesian sequential updating over datasets. This talk will discuss the concept of the PPL, describe the complexity of cleft lip with our without cleft palate (CL/P), and present some of our recent findings.