Xinghua Lu, MD, PhD, MS

Yan G, Chen V, Lu X, Lu S. A signal-based method for finding driver modules of breast cancer metastasis to the lung. Sci Rep. 2017 Aug 30; 7(1):10023. doi: 10.1038/s41598-09951-2. PMID: 28855549. PMC ID: PMC5577160.

Chen V, Paisley J, Lu X. Revealing common disease mechanisms shared by tumors of different tissues of origin through semantic representation of genomic alterations and topic modeling. BMC Genomics. 2017 Mar 14;18 (Suppl 2):105. doi: 10.1186/s12864-017-3494-z. PMID: 28361690. PMC ID: PMC5374647.

Watters RJ, Hartmaier RJ, Osmanbeyoglu HU, Gillihan RM, Rae JM, Liao L, Chen K, Li W, Lu X, Oesterreich S. Steroid receptor coactivator-1 can regulate osteoblastogenesis independently of estrogen. Mol Cell Endocrinol. 2017 Jun 15; 448:21-27. doi: 10.1016/j.mce.2017.03.005. Epub 2017 Mar 7. PMID: 28286232

Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):840-855.e8. doi: 10.1016/j.ccell.2017.11.005. PMID: 29232556

Ding MQ, Chen L, Cooper GF, Young JD, Lu X. Precision Oncology Beyond Targeted Therapy: Combining Omics Data with Machine Learning Matches the Majority of Cencer Cells to Effective Therapeutics. Mol Cancer Res. 2017 Nov 13. pii: molcanres.0378.2017. doi: 10.1158/1541-7786.MCR-17-0378. [Epub ahead of print] PMID: 29133589

Young JD, Cai C, Lu X. Unsupervised deep learning reveals prognostically relevant subtypes of glioblastoma. BMC Bioinformatics. 2017 Oct 3;18(Suppl 11): 381. doi: 10.1186/s12859-017-1798-2. PMID: 28984190. PMCID: PMC5629551

S. Lu, C. Cai,  G. Yan,  Z. Zhou, Y. Wan, L. Chen, V. Chen, G. Cooper, L. Obeid, Y. Hannun, A. Lee and X. Lu. Signal-oriented pathway analyses reveal a signaling complex as a synthetic lethal target for p53 mutations, Cancer Research 2016, Minor revision

Lu, S., Mandava, G., Yan, G., and Lu, X (2016) An exact algorithm for finding cancer driver somatic genome alterations: the weighted mutually exclusive maximum set cover problem.  Algorithm for Molecular Biology 11:1, DOI: 10.1186/s13015-016-0073-9   PMCID: PMC4855522

Stolovitzky, G., Hill, S., Heiser, L, Lu, X, Jiang, X, et al.  (2016) Inferring causal molecular networks: empirical assessment through a community-based effort.  Nature Methods. 13, 310–318 PMID: 26901648 PMCID: PMC4854847

 

Chen, L., Cai, C., Chen, V., and Lu, X (2015) Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model.  BMC Bioinformatics Suppl 1:9. doi: 10.1186/s12859-015-0852-1. PMID: 26818848  PMCID: PMC4895523

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