Faculty
Xinghua Lu, MD, PhD, MS
Research Interests
Dr. Lu’s research focuses on the computational methods for identifying signaling pathways underlying biological processes and diseases as well as statistical methods for acquiring knowledge from biomedical literature. He was trained in Pharmacology and works in the field of bioinformatics after NLM sponsored postdoctoral training in Biomedical Informatics. His research interest concentrates on applying latent variable models to simulate biological signaling system and text mining.
Currently, Dr. Lu is working on developing his research in translational bioinformatics and systems/computational biology and its application to specific domains relevant to human disease. He is pursuing collaboration in the area of natural language processing and text mining with the eventual goal of establishing a Center or Institute in Translational Bioinformatics.
Appointments and Positions
Associate Professor of Biomedical Informatics
Biomedical Informatics Training Program Core Faculty
Recent Publications
Cowart, LA., Shotwell, M., Worley, ML., Richards, AJ, Montefusco, DJ, Hannun YA, and Lu, X. (2010) Revealing a signaling role of PHS1P in yeast using integrative systems approaches. Molecular Systems Biology 6:349 PMID: 20160710(Selected for presentation at the Highlight Track of ISMB 2010 as a major advance in the field)
Richards*, AJ, Muller, B., Shotwell, M, Cowart, LA, Rohrer, B, and Lu, X (2010) Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph. Bioinformatics, supplement issue for the Proceedings for the Intelligent Systems in Molecular Biology (ISMB) 2010 (19% acceptance) PMID: 20529941
Zheng*, B. and Lu, X (2009) Application of semantic modeling in bioinformatics domain. In: Data Management in Semantic Web, Ed. Jin, H. and Lv, Z,. Nova Science Publishers, Inc.
Jin*, B and Lu, X (2009) Enhancing GO-graph-based multi-label classification using semantic-rich GO terms. Proceedings of the Annual Meeting of the ISMB BioLINK Workshop 2009
Muller*, B., Richards, AJ., Jin, B., Lu, X. (2009) GOGrapher; A Python library for GO graph representation and analysis. BMC Research Notes 2:122 PMID:19583843