Songjian Lu, PhD

Room 512
5607 Baum Boulevard
Admin Support: 
Research Interests: 
  • Using computational method to search for driver somatic genome alterations, such as somatic mutations, copy number alterations, that are related to cancer development.
  • Formulating the biological problems into graph or statistical problems.
  • Designing efficient exact algorithms for the hard computational problems.
Assistant Professor, Department of Biomedical Informatics
University of Pittsburgh School of Medicine

Yan G, Chen V, Lu X, Lu S. A signal-based method for finding driver modules of breast cancer metastasis to the lung. Sci Rep. 2017 Aug 30; 7(1):10023. doi: 10.1038/s41598-09951-2. PMID: 28855549. PMC ID: PMC5577160.

Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):840-855.e8. doi: 10.1016/j.ccell.2017.11.005. PMID: 29232556

Lu, S., Jin, B., Cowart, LA., and Lu, X (2013) From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data. PLoS One 8(4): e61134  PMID: 23637789 PMCID: PMC3634064



S. Lu, K. Lu, X. Ma, N. Nystrom, X. Lu, Identifying driver genomic alterations in cancers by searching minimum-weight, mutually exclusive sets, PLOS Computational Biology 2015; DOI: 10.1371 /journal.pcbi.100425.

S. Lu, X. Lu. Using graph model to find transcription factor modules: the hitting set problem and an exact algorithm. Algorithms for Molecular Biology. 2013; 8(2).

S. Lu, B. Jin, L. Cowart, X. Lu. From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data. PLOS One. 2013; 8(4).

D. Montefusco, L. Chen, N. Matmati, S. Lu, B. Newcomb, G. Cooper, Y. Hannun, X. Lu. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Since Signaling. 2013; 6(229).

S. Lu, X. Lu. Integrating Genome and Functional Genomics Data to Reveal Perturbed Signaling Pathways in Ovarian Cancers. In: Proc. 2012 AMIA Joint Summits on Translational Science (AMIA-TBI); 2012 Mar 19-23; San Francisco, CA.

H. Feng, B. Hu, K. Liu, Y. Li, X. Lu, T. Cheng, J. Yiin, S. Lu, S. Keezer, T. Fenton, F. Furnari, R. Hamilton, K. Vuori, J. Sarkaria, M. Nagane, R. Nishikawa, W. Cavenee, S. Cheng. Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRa-stimulated glioma tumorigenesis in mice and humans. The Journal of Clinical Investigation. 2011; 121 (12):4670-4684.

S. Lu, X. Lu. A graph model and an exact algorithm for finding transcription factor modules. In: Proc. 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine (ACM-BCB); 2012 Jul 31-Aug 3; Chicago, IL. 355-359.
Chen J, Kneis J, Lu S, Mölle D, Richter S, Rossmanith P, Sze S, Zhang F. Divide-and-Conquer for Path and Packing Problems. SIAM Journal on Computing. 2009; 38 (6):2526-47.

Chen J, Liu Y, Lu S, O’Sullivan B, Razgon I. A Fixed-Parameter Algorithm for the Directed Feedback Vertex Set Problem. Journal of the ACM. 2008; 55 (5). doi: 10.1145/1411509.1411511.
Chen J, Fomin F, Liu S, Lu S, Villanger Y. Improved Algorithms for the Feedback Vertex Set Problems. J Comp Sys Sci. 2008; 74 (7):1188-98.