Michael J. Becich, MD, PhD

Room 521
5607 Baum Boulevard
Phone: 
412-648-9244
412-606-6453
Fax: 
412-624-5310
Website: 
http://www.dbmi.pitt.edu/person/michael-j-becich-md-phd
Admin Support: 
Research Interests: 

   • Translational Bioinformatics
   • Pathology Informatics
   • Oncology Informatics
   • Tissue Banking Informatics
   • Research Resource Development
   • Personalized Medicine

Chairman and Distinguished University Professor, Department of Biomedical Informatics
Professor of Pathology, Information Sciences, Telecommunications and Clinical/Translational Sciences
Associate Vice Chancellor for Informatics in the Health Sciences
Director, Center for Commercial Application (CCA) of Healthcare Data
Associate Director for Cancer Institute (UPCI)
Associate Director, Clinical and Translational Science Institute (CTSI)
University of Pittsburgh School of Medicine
Selected Publications: 

Jacobson RS, Becich MJ, Bollag RJ, Chavan G, Dhir R, Corrigan J, Feldman M, Ganguly A, Gaudioso C, Legowski E, Maihle N, Mitchell K, Murphy M, Sakthivel M, Tseytlin E, Weaver J.  A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.  Cancer Research 2015;75(24):5194-201. PMID:26670560 PMCID:PMC4683415 [Available on 2016-12-15]

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R, Center for Causal Discovery team. The Center for causal discovery of biomedical knowledge from Big Data. Journal of the American Medical Informatics Association 2015 Jul 2. pii: ocv059. doi: 10.1093/jamia/ocv059. [Epub ahead of print]  PMID: 26138794

Amin W, Tsui FC, Borromeo C, Chang CH, Espino JU, Ford D, Hwang W, Kapoor W, Lehmann H, Martich GD, Morton S, Paranjape A, Shirey W, Sorensen A, Becich MJ, Hess R. PaTH: towards a learning health system in the Mid-Atlantic region. J Am Med Inform Assoc.. 2014;21(4):63-6, PMID: 24821745 PMCID: PMC4078296

Amin W, Srinivasan M, Song SY, Parwani AV, Becich MJUse of automated image analysis in evaluation of mesothelioma Tissue Microarray (TMA) from National Mesothelioma Virtual Bank. Pathology Research and Practice 2014 Feb. 210(2) 79-82. doi: 10.1016/j.prp.2013.09.002 Epub 2013 Nov 14.

Risinger JI, Allard J, Chandran U, Day R, Chandramouli GV, Miller C, Zahn C, Oliver J, Litzi T, Marcus C, Dubil E, Byrd K, Cassablanca Y, Becich M, Berchuck A, Darcy KM, Hamilton CA, Conrads TP, Maxwell GL. Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion. Front Oncol. 2013 Jun 17;3:139. doi: 10.3389/fonc.2013.00139. Print 2013. PMID: 23785665

Park S, Parwani AV, Aller RD, Banach L, Becich MJ, Borkenfeld S, Carter AB, Friedman BA, Rojo MG, Georgiou A, Kayser G, Kayser K, Legg M, Naugler C, Sawai T, Weiner H, Winsten D, Pantanowitz L. The history of pathology informatics: A global perspective. J Pathol Inform. 2013 May 30;4:7. doi: 10.4103/2153-3539.112689

Amin W, Parwani A, Melamed J, Flores R, Pennathur A, Valdivieso F, Whelan N, Landreneau R, Luketich J, Feldman M, Pass H, and Becich MJNational Mesothelioma Virtual Bank: A Platform for Collaborative Research and Mesothelioma Biobanking Resource to Support Translational Research. Lung Cancer International, Volume 2013, Article ID 765748.

Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. J Pathol Inform. 2012;3:41. doi: 10.4103/2153-3539.103995. Epub 2012 Nov 28. PMID: 23248762

Gullapalli RR, Desai KV, Santana-Santos L, Kant JA, Becich MJNext generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics. J Pathol Inform. 2012;3:40. doi: 10.4103/2153-3539.103013. Epub 2012 Oct 31. PMID:  23248761

Gullapalli RR, Lyons-Weiler M, Petrosko P, Dhir R, Becich MJ, LaFramboise WA. Clinical integration of next-generation sequencing technology. Clin Lab Med. 2012 Dec;32(4):585-99. doi: 10.1016/j.cll.2012.07.005. Review. PMID: 23078661

Jiang X, Barmada MM, Becich MJEvaluating de novo locus-disease discoveries in GWAS using the signal-to-noise ratio. AMIA Annu Symp Proc. 2011;2011:617-24. Epub 2011 Oct 22. PMID: 22195117 

Amin W, Singh H, Pople AK, Winters S, Dhir R, Parwani AV, Becich MJ. A decade of experience in the development and implementation of tissue banking informatics tools for intra and inter-institutional translational research. Journal of Pathology Informatics. 2010 Aug 10; 1.12. PMID: 20922029. PMCID: PMC2941965. doi: 10.4103/2153-3539.68314

Yin M, Bastacky S, Chandran U, Becich MJ, Dhir R. Prevalence of incidental prostate cancer in the general population: a study of healthy organ donors. The Journal of Urology. 2008 Mar;179(3):892-5; discussion 895. PMID: 18207193 DOI: 10.1016/j.juro.2007.10.057

Chandran UR, Ma C, Dhir R, Bisceglia M, Lyons-Weiler J, Liang W, Michalopoulos GK, Becich MJ, Monzon FA. Gene expression profiles of metastatic prostate cancer reveals disregulation of specific molecular pathways. BMC Cancer. 2007;7(0):64. PMID: 17430594 PMCID: PMC1865555

Kelavkar UP, Harya NS, Hutzley J, Bacich DJ, Monzon FA, Chandran U, Dhir R, O'Keefe DS. DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. Prostaglandins & other lipid mediators. 2007 Jan;82(1):185-97. PMID: 17164146 DOI: 10.1016/j.prostaglandins.2006.05.015

Chandran, U. R., Dhir, R., Ma, C., Michalopoulos, G., Becich, M., & Gilbertson, J. (2005). Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors. BMC Cancer, 5, 45. http://doi.org/10.1186/1471-2407-5-45 PMID: 15892885 PMCID: PMC1173092

Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, Shah RB, Chandran U, Monzon FA, Becich MJ, Wei JT, Pienta KJ, Ghosh D, Rubin MA, Chinnaiyan AM. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer cell. 2005 Nov;8(5):393-406. PMID: 16286247

Chandran U, Monzon FA, Becich MJ, Gilbertson J. A new pathology biomarker laboratory. Proc. Medinfo. (CD). 2004;(0):1546.

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