Learning patient-specific predictive models from clinical data

Visweswaran S, Angus DC, Hsieh M, Weissfeld L, Yealy D, Cooper GF.  Learning patient-specific predictive models from clinical data.  Journal of Biomedical Informatics 43 (2010) 669-685.  PMID: 20450985 PMCID: PMC2933959.

We introduce an algorithm for learning patient-specific models from clinical data to predict outcomes. Patient-specific models are influenced by the particular history, symptoms, laboratory results, and other features of the patient case at hand, in contrast to the commonly used populationwide models that are constructed to perform well on average on all future cases. The patient-specific algorithm uses Markov blanket (MB) models, carries out Bayesian model averaging over a set of models to predict the outcome for the patient case at hand, and employs a patient-specific heuristic to locate a set of suitable models to average over. We evaluate the utility of using a local structure representation for the conditional probability distributions in the MB models that captures additional independence relations among the variables compared to the typically used representation that captures only the global structure among the variables. In addition, we compare the performance of Bayesian model averaging to that of model selection. The patient-specific algorithm and its variants were evaluated on two clinical datasets for two outcomes. Our results provide support that the performance of an algorithm for learning patient-specific models can be improved by using a local structure representation for MB models and by performing Bayesian model averaging.

Publication Year: 
2010
Publication Credits: 
Visweswaran S, Angus DC, Hsieh M, Weissfeld L, Yealy D, Cooper GF.
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