Richard Boyce, PhD

Research Interests: 
  • Informatics interventions to improve medication safety, especially for older adults 
  • Structured publishing of biomedical knowledge and data to improve information retrieval and knowledge synthesis
  • Computational methods for simplifying biomedical knowledge-base development, curation, and use

Conference Papers and Presentations at National and Local Meetings:


Schneider, J., Brochhausen, M., Rosko, S., Ciccarese, S., Hogan, WR., Malone, D., Ning, Y., Clark, T., and Boyce, RD. Formalizing knowledge and evidence about potential drug-drug interactions. The International Workshop on Biomedical Data Mining, Modeling, and Semantic Integration: A Promising Approach to Solving Unmet Medical Needs (BDM2I 2015) at the 14th International Semantic Web Conference (ISWC). October 11th 2015. Bethlehem, PA.

Brochhausen, M., Schneider, J., Malone, D., Empey, PE., Hogan WR., and Boyce, RD. Towards a foundational representation of potential drug-drug interaction knowledge. The 1st International Drug-Drug Interaction Knowledge Representation Workshop (DIKR 2014). Collocated with the 2014 International Conference on Biomedical Ontology (ICBO 2014). October 6th, Houston, Texas. United States.

Schneider, J., Ciccarese, P., Clark, T., Boyce, RD. Using the Micropublications ontology and the Open Annotation Data Model to represent evidence within a drug-drug interaction knowledge base. The 4th Workshop on Linked Science 2014— Making Sense Out of Data (LISC2014). Collocated with the 13th International Semantic Web Conference (ISWC2014). October 19th and 20th, Riva del Garda, Trentino, Italy.

Boyce RD., Handler SM., Karp JF., Perera, S., Hanlon JT. Prevalence of Potential Drug-Drug Interactions Affecting Antidepressant in US Nursing Home Residents. Poster presentation at the 2013 Aging Institute Research Day. University of Pittsburgh. Pittsburgh PA. April, 2013.

Samwald, M., Freimuth, R., Powers, R., Luciano, J., Prud’hommeaux, E., Boyce, R., Marshall, M., Dumontier, M. An Ontology-based Formalism, Knowledge Base and Reasoning System for Clinical Genetics. Poster presentation at the 2013 AMIA Summit on Translational Bioinformatics.San Francisco, March, 2013.

Guzman, RJ., Boyce RD. The Influence of Drug Terminologies on the Performance of the NCBO Annotator When Used to Identify Drug Entities in Drug Product Labels. Poster presentation to be presented at the 2012 Conference of the American Medical Informatics Association. Washington DC. November 2012.

Boyce, RD., Hassanzadeh, O., Pathak, J., de Waard, A., Schneider, J., Liakata, M., “Dynamic enhancement of drug product labels through semantic web technologies.” Poster presentation at the Eighth International Conference on Data Integration in the Life Sciences (DILS 2012). Washington DC. June, 2012.

Boyce, R., Hanlon, J., Handler, S. “A systematic review of studies examining the effectiveness of antidepressants for treating depressed nursing home residents,” Poster presentation at the 17th Annual NRSA Trainee Research Conference. Seattle, WA. June, 2011.

Boyce, R. “The Drug Interaction Knowledge Base -- an evidential approach to predicting metabolic drug-drug interactions,” Poster presentation at the 2011 Epistemology of Modeling and Simulation National Conference, April 2011.

Associate Professor, Department of Biomedical Informatics
Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
Faculty, Center for Pharmaceutical Policy and Prescribing
University of Pittsburgh School of Medicine
Selected Publications: 

Freimuth, R. R., Formea, C. M., Hoffman, J. M., Matey, E., Peterson, J. F. and Boyce, R. D. (2017), Implementing Genomic Clinical Decision Support for Drug-Based Precision Medicine. CPT Pharmacometrics Syst. Pharmacol.. Accepted Author Manuscript. doi:10.1002/psp4.12173

Hochheiser, H., Ning, Y., Hernandez, A., Horn, J. R., Jacobson, R., & Boyce, R. D. (2016). Using Nonexperts for Annotating Pharmacokinetic Drug-Drug Interaction Mentions in Product Labeling: A Feasibility Study. JMIR Research Protocols, 5(2), e40. PMID: 27066806 PMCID: PMC4844909

Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements. Romagnoli KM, Boyce RD, Empey PE, Adams S, Hochheiser H. International Journal of Medical Informatics , Volume 86 , 54 - 61 PMID: 26725696 PMCID: PMC4720137 [Available on 2017-02-01]

E.A. Voss, R.D. Boyce, P.B. Ryan, J. van der Lei, P.R. Rijnbeek, M.J.Schuemie, Accuracy of an Automated Knowledge Base for Identifying Drug Adverse Reactions, Journal of Biomedical Informatics, Available online 16 December 2016, ISSN 1532-0464,

Samwald M, Xu H, Blagec K, Empey PE, Malone DC, Ahmed SM, Boyce, RD, et al. (2016) Incidence of Exposure of Patients in the United States to Multiple Drugs for Which Pharmacogenomic Guidelines Are Available. PLoS ONE 11(10): e0164972. PMID: 27764192  DOI: 10.1371/journal.pone.0164972

Boyce RD, Handler SM, Karp JF, Perera S, Reynolds CF 3rd. Preparing Nursing. Home Data from Multiple Sites for Clinical Research - A Case Study Using Observational Health Data Sciences and Informatics. EGEMS (Wash DC). 2016 Oct 26;4(1):1252. PubMed PMID: 27891528. DOI:

Huser, Vojtech; DeFalco, Frank J.; Schuemie, Martijn; Ryan, Patrick B.; Shang, Ning; Velez, Mark; Park, Rae Woong; Boyce, Richard D.; Duke, Jon; Khare, Ritu; Utidjian, Levon; and Bailey, Charles (2016) "Multisite Evaluation of a Data Quality Tool for Patient-Level Clinical Datasets," eGEMs (Generating Evidence & Methods to improve patient outcomes): Vol. 4: Iss. 1, Article 24. DOI:

Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), 206-217.  DOI:10.1016/j.jbi.2015.04.006. PMID 25917055

Pfundner , A., Schönberg, T., Horn., J., Boyce, RD., and Samwald, M. Utilizing the Wikidata system to improve the quality of medical content in Wikipedia in diverse languages: a pilot study. Journal of Medical Internet Research. 2015; 17(5). .PMCID: PMC4468594

Romagnoli, KM., Boyce, RD., Empey, PE., Adams, S., Hochheiser, H., Bringing clinical pharmacogenomics information to pharmacists: a qualitative study of information needs and resource requirements. International Journal of Medical Informatics. 2015 Nov.  DOI:

Samwald M, Miñarro Giménez JA, Boyce RD, Freimuth RR, Adlassnig K-P, Dumontier M. Pharmacogenomic knowledge representation, reasoning and genome-based clinical decision support based on OWL 2 DL ontologies. BMC MedRical Informatics and Decision Making. 2015;15:12. doi:10.1186/s12911-015-0130-1.  PubMed4340468


Scheife RT, Hines LE, Boyce RD, Chung SP, Momper JD, Sommer CD, Abernethy DR, Horn JR, Sklar SJ, Wong SK, Jones G, Brown ML, Grizzle AJ, Comes S, Wilkins TL, Borst C, Wittie MA, Malone DC. Consensus Recommendations for Systematic Evaluation of Drug-Drug Interaction Evidence for Clinical Decision Support. Drug Saf. 2015 Jan 3.  [Epub ahead of print] PubMed PMID: 25556085. [PMCID – in process]

Boyce. RD., Ryan. PB., Noren. N., et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest.  Drug Safety. 2014. DOI: 10.1007/s40264-014-0189-0

Ayvaz, S., Zhu, Q., Hochheiser, H., Brochhausen, M., Horn, J., Dumontier, M., … Boyce, R. D. (2014). Drug-Drug Interaction Data Source Survey and Linking. AMIA Summits on Translational Science Proceedings, 2014, 16. PMID: 25717393 PMCID: PMC4333686

Rasteger-Mojarad, M., Boyce RD., Prasad, R. UWM-TRIADS: Classifying Drug-Drug Interactions with Two-Stage SVM and Post-Processing. Proceedings of the 2013 International Workshop on Semantic Evaluation (SemEval), Task 9 - Extraction of Drug-drug Interactions from BioMedical Texts. Atlanta Georgia, June 2013.

Boyce, RD., Freimuth, RR., Romagnoli, KM., Pummer, T., Hochheiser, H., Empey, PE. Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support. Proceedings of the 2013 AMIA Summit on Translational Bioinformatics. San Francisco, March 2013. [PMCID – in process] PDF

Hassanzadeh, O., Zhu, Qian., Freimuth, RR., Boyce R. Extending the “Web of Drug Identity” with Knowledge Extracted from United States Product Labels. Proceedings of the 2013 AMIA Summit on Translational Bioinformatics. San Francisco, March 2013. [PMCID – in process] PDF

Handler SM, Boyce RD, Ligons FM, Perera S, Nace DA, Hochheiser H. Use and Perceived Benefits of Mobile Devices by Physicians in Preventing Adverse Drug Events in the Nursing Home. J Am Med Dir Assoc. 2013 Oct 2. doi: 10.1016/j.jamda.2013.08.014. pii: S1525-8610(13)00472-6. Epub 2013 Oct 2. PubMed PMID: 24094901. [PMCID - in process]

Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Biomed Semantics. 2013 Jan 26;4(1):5. [Epub ahead of print] DOI 10.1186/2041-1480-4-5 PMID:23351881. [PMCID – in process]

Rodríguez-González, A., Pathak, J., Wilkinson, MD., Shah, NH., Stevens, R., Boyce, RD., García-Crespo, Á., “Proceedings of the Joint Workshop on Semantic Technologies Applied to Biomedical Informatics and Individualized Medicine (SATBI+SWIM 2012),” Held at the 11th International Semantic Web Conference (ISWC 2012), November 12th, Boston, USA.

Marshall MS., and Boyce RD, (Eds). Health Care and Life Science (HCLS) Linked Data Guide. World Wide Web Consortium (W3C). November 2012.