Archived Talks

University of Pittsburgh Department of Biomedical Informatics Lecture Announcement

Speaker: Jill Hagenkord, MD
Department of Pathology

Friday, August 31, 2007
11:00 AM to 12:00 noon
Room M-184 VALE [?]
200 Meyran Avenue

Topic: DNA Genome Arrays for High-Resolution, Whole-Genome Assessment of Chromosomal Aberrations: A Beginner’s Guide

Abstract: Array Comparative Genomic Hybridization (aCGH) and oligonucleotide SNP arrays can be used to detect copy number changes in the genome at high resolution. Clinically, copy number aberrations are currently detected using conventional karyotyping and FISH for both constitutional syndromes and cancers. Conventional karyotyping offers a whole genome view, but at a very course resolution. FISH is very high-resolution for the locus being investigated, but one FISH probe can see only one locus and thus does not provide a whole genome view. DNA genome arrays overcomes the limitations of both of these platforms in that they provide high-resolution, whole genome assessment of copy number changes. In addition, these arrays are relatively inexpensive, QC manufactured, do not require fresh tissue, have a rapid turn-around time, provide quantiative and graphic output that is familar to physicians and clinical genecists. All of these features make DNA genome arrays likely to become the first array-based testing platform to enter routine clinical use.

This talk will give a beginner’s level overview of the biology, the platform, and the clinical utility. The bioinformatics solutions with their strengths and limitations will be woven into the talk.

For more information: jxc3@pitt.edu or 412.647.7113